Cas 77-86-1 Biological buffer trihydroxymethylaminomethane In Eye Drops Tris Buffer Solution

TRIS has two main functions in eye drops:

1. Adjust the PH value of eye drops

Eye drops are one of the most commonly used drug formulations for ophthalmological diseases. For many eye diseases, eye drops have a direct and rapid therapeutic effect. Due to the special anatomical and physiological characteristics of the eyes, corresponding requirements are put forward for ophthalmic preparations: the pH of normal tears is 7.2 to 7.4, and the range of pH tolerated by normal eyes is 5.0 to 9.0. The pH value of the eye drops will directly affect the eye irritation and the curative effect of the drug. When preparing eye drops, a buffer should be added to adjust the pH of the solution so that it is roughly similar to the tear fluid to reduce the impact on the eyes. Stimulus. At the same time, adjusting the pH value also needs to take into account multiple factors such as drug solubility and stability. TRIS base is a commonly used pH regulator in eye drops.

2. As an intermediate of active ingredients.

As an organic amine, TRIS can form a double salt that is easily soluble in water. The most common eye drops containing TRIS are ketorolac tromethamine eye drops. Ketorolac is a non-steroidal anti-inflammatory drug for injection. Ketorolac tromethamine is soluble in water and stable in aqueous solution, with antipyretic, analgesic and anti-inflammatory effects. It reversibly inhibits cyclooxygenase and deoxygenase, thereby inhibiting the biosynthesis of prostaglandins, thereby reducing the response of painful nerves to endogenous inflammatory factors, inhibiting peripheral nerve sensitization, and achieving the purpose of advanced analgesia. Ketorolac tromethamine eye drops are often used for inflammation and pain after eye surgery.

TRIS powder

After understanding the role of TRIS in eye drops, it can be found that as a drug that can be used for acute metabolic acidosis and acute respiratory acidosis, TRIS itself can be used in humans. In addition, when we talk about the toxicity of any substance, we can't break away from the dose. As a buffer, there are not many additives, and there will be no safety hazards in normal use. Secondly, animal experiments and clinical studies have shown that ketorolac tromethamine eye drops can significantly reduce corneal sensitivity, have strong analgesic and anti-inflammatory effects, and have no obvious adverse reactions and high safety.

In summary, eye drops containing TRIS are safe. However, although most eye drops are not prescription drugs, in principle, there is no need for regular use of eye drops. If eye discomfort occurs, it is best to seek medical treatment in time. Only when the cause of the disease is identified can the appropriate drugs be selected to relieve the symptoms, achieve the best therapeutic effect, and avoid the harm caused by the wrong drug use.

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