Wuhan Desheng Biochemical Technology Co., Ltd

1.Carbopol solvent residue: a common quality challenge in the pharmaceutical and daily chemical industries Carbomer (polyacrylic acid resin) is an indispensable rheological modifier in the fields of medicine, personal care, and industry, with three core functions of thickening, suspension, and emulsification. However, due to the introduction of various organic solvents such as benzene, ethyl acetate, and cyclohexane in its preparation process, residual carbomer solvents have always been a key quality problem that troubles the industry. According to the 2025 edition of the Chinese Pharmacopoeia, the key limits for residual solvents in carbomer are: benzene should not exceed ≤ 2ppm, ethyl acetate should not exceed 0.5%, and cyclohexane should not exceed 0.3%. For Carbopol products applied in the fields of pharmaceutical excipients, high-end cosmetics, and medical devices, solvent residue control is directly related to product compliance and user safety. How to control residual solvents in Carbopol? This is a question that every Carbopol production technician is thinking about. Hubei Xindesheng Material Technology Co., Ltd., in collaboration with the Quality Department, has launched a special technical research and development project to address common challenges in this industry. 2.Technical Root Analysis of Carbopol Solvent Residue To fundamentally solve the problem of residual solvents in Carbopol, the New Desheng Technology Department and Quality Department have established a special research and development team to conduct a systematic investigation of the existing Carbopol production process. After multiple rounds of analysis and verification, the research team has identified the key factors affecting the residual Carbopol solvent, which mainly focus on the following aspects: (1) Selection of solvent system for polymerization stage Traditional carbomers (such as carbomer 940, carbomer 934, etc.) use benzene as the polymerization solvent, which poses a high risk of residual solvents. How to optimize the solvent system while ensuring polymerization efficiency is a key research topic. (2) The efficiency issue of washing process After polymerization, the crude carbomer still contains a large amount of unreacted solvents, initiators, polymerization inhibitors, and other residues. The traditional washing process has the problem of insufficient efficiency in removing these impurities. (3) Insufficient refinement of drying process Improper control of drying temperature and time may result in incomplete solvent evaporation or thermal discoloration of the product. Research has shown that when the drying temperature exceeds 120 ℃, the product will exhibit varying degrees of light yellow color. 3.Optimization of Carbopol Production Process: Stage Results After a long period of research and development, the special team has made breakthroughs in optimizing the production process of Carbopol: (1) Optimization and upgrade of Carbopol washing process The research team has systematically optimized the washing process of crude carbomer. Research has shown that washing newly prepared carbomer with ethanol aqueous solutions of different mass fractions can effectively remove residual initiators, inhibitors, and other impurities. The team further optimized parameters such as washing temperature, washing frequency, and solvent ratio, resulting in a significant increase in impurity removal rate. (2) Fine control of Carbopol drying process The research team has established the core process route of low-temperature vacuum drying, strictly controlling the drying temperature at a certain temperature. At the same time, a temperature time vacuum linkage control model was established to achieve precision and standardization of the carbomer drying process. (3) Establish a process control system for residual solvents in Carbopol The quality department has set up sampling and testing points for residual solvents in key processes such as aggregation, washing, and drying, achieving a transition from "terminal inspection" to "process control". (4) Improvement of Carbopol Solvent Residue Index After process optimization, the solvent residue of the company's carbomer was significantly reduced. The key residual solvent indicators such as ethyl acetate and cyclohexane have been stably controlled within the limits, and some indicators are better than the internal control standards. By optimizing the carbomer washing process, refining the drying process, and establishing a process control system, New Desheng has made substantial breakthroughs in controlling residual solvents in carbomer. The next article will focus on the synchronous upgrade of detection capabilities - providing a detailed introduction to the company's new gas chromatography (GC) equipment configuration, optimization of carbomer residual solvent detection methods, and improvement of quality control systems.

As of August 2026, all 66 domestic IVD listed companies have disclosed their semi annual reports. The three rankings of revenue, growth rate, and net profit show an unprecedented "misalignment" - some companies have seen revenue growth of over 30% but are still losing money, while others have seen a significant improvement in profits despite a decrease in revenue. Through this report card, a clear signal is being released: China's IVD has bid farewell to the stage of widespread growth relying on market expansion and officially entered the era of testing business quality. 1．Half year report 'misalignment': growth and profitability are decoupling According to the total revenue ranking, Fosun Pharma and Mindray lead with 20.442 billion yuan and 17.747 billion yuan respectively, but only 4 out of the top ten companies have achieved positive revenue growth, and most top companies have not yet escaped the pressure of industry adjustment. More noteworthy is the divergence between growth and profitability. Among the top ten companies in terms of total revenue growth rate, Re Jing, Kangwei Century, Wantai, Huada Intelligent Manufacturing, and Yirui are still in a loss making state; Pumen Technology's revenue increased by 19.15%, but its net profit decreased by 34.80%. On the other hand, Dean Diagnostics' net profit surged by 2160%, but profit growth mainly relied on cost reduction and efficiency improvement, as well as narrowing credit impairment losses - some companies' performance improvements were "saved" rather than "earned". Among the top ten companies in terms of net profit, only the top three companies have a combined net profit of nearly 9.6 billion yuan, accounting for 68.26% of the total net profit of 66 enterprises. The concentration of the top is extremely high, and on the loss making list, five companies including Oriental Biotechnology, Huada Intelligent Manufacturing, Wantai, Rejing, and Kehua have not crossed the breakeven line despite their positive revenue growth. 2． Why is it easy to increase income but difficult to increase profits? The normalization of centralized procurement, mutual recognition of inspection results, and DRG payment reform continue to exert multiple pressures on industry profits. In the first quarter of 2026, 43 out of 64 IVD companies were operating at a loss. When terminal reagent prices are continuously compressed, raw material costs - the largest variable cost in reagent production - become the key variable determining whether a company can make profits. Industry analysis indicates that the profit pool of the industrial chain is shifting towards upstream raw materials and downstream scale platforms. With midstream manufacturers facing extreme cost control pressure, their demand for localization of core raw materials such as enzymes, buffering agents, color substrates, etc. is unprecedentedly high. The upstream core raw materials are accelerating the breakthrough of import dependence, and the domestication rate of midstream instruments and reagents continues to rise. Mindray Medical acquired the globally renowned IVD raw material company, Hai Peptide Biotechnology, in 2021, achieving independent and controllable core technology in the field of chemiluminescence raw materials; The self-sufficiency rate of core raw materials for Mike Biology has increased to over 70%. The actions of top enterprises have already demonstrated that raw material autonomy is not just a bonus, but a bottom line for survival. 3．New Desheng's perspective: Where are we located? Hubei Xindesheng Material Technology Co., Ltd. has been deeply involved in the IVD reagent raw material track for 20 years, focusing on the research and production of core products such as biological buffering agents, enzyme preparations, color substrates, and blood collection tube additives. In 2026, the company was selected as a single champion enterprise in the manufacturing industry in Hubei Province. The data from the semi annual report confirms our long-term judgment: when terminal prices are pushed to the limit by centralized procurement, the quality and cost efficiency of upstream raw materials can truly help reagent manufacturers maintain their profit bottom line. Biological buffering agents: more than 50 products including Tris, HEPES, MOPS, etc., with a stable purity of over 99%. High purity means fewer inter batch differences and lower repeat detection rates - this is an implicit cost savings. Enzyme preparations: lactate dehydrogenase (LDH), uricase (UO), creatine kinase isoenzyme (CK-MB), etc., with high activity and stability, help reagent manufacturers achieve better detection performance with less raw material usage. Chromogenic substrates: TOOS, MAOS, ALPS, etc. benchmark against international standards; EPS-G7 amylase substrate and DGGR lipase substrate have achieved kilogram scale mass production - reagent manufacturers can get rid of import dependence and obtain stable and more cost-effective supply. Blood collection tube additives: heparin lithium, heparin sodium, EDTA dipotassium/tripotassium, serum separation gel, etc., covering the entire process of blood sample pretreatment. The company has two R&D and production bases in Gedian and Huanggang (70 acres), with an annual production capacity of 5000 tons for all categories. The truth revealed by 66 semi annual reports is that the industry has entered a stage of stock competition, where the competition is no longer about whose channels are wider and whose brands are louder, but whose supply chain is deeper, raw material costs are lower, and quality is more stable. For IVD reagent manufacturers, in an era where increasing revenue is easy but increasing profits is difficult, upstream raw materials are the "watershed". New Desheng will continue to focus on the research and production of IVD reagent raw materials, using higher quality and more cost-effective products to help partners build true cost barriers in the industry reshuffle. Hubei Xindesheng Material Technology Co., Ltd. - Focusing on IVD reagent raw materials to assist in accurate diagnosis

Since 2026, the daily chemical raw material industry has undergone a profound round of cost impact and competition logic reconstruction. The price of crude oil once exceeded $100 per barrel, and the price of surfactants fluctuated at a high level. Cosmetics efficacy raw material companies successfully landed in the capital market. At the same time, industry competition is shifting from "low price competition" to a comprehensive competition of "quality and technology". Multiple signals are superimposed, and the daily chemical raw material industry is standing at a critical turning point. 1. Soaring oil prices, cost pressures transmitted along the industrial chain In March 2026, influenced by the situation in the Middle East, international crude oil prices broke through $100 per barrel for the first time in nearly four years. Some oil analysts warn that if the situation does not ease, oil prices may further rise. The soaring oil prices have directly pushed up the production costs of petroleum based daily chemical raw materials. Most surfactants in washing products such as laundry detergent and laundry detergent rely on petroleum resources, and the rising cost of raw materials is rapidly transmitted along the industry chain. 2. Surfactant prices: High level operation, fluctuating differentiation The cost impact has been fully reflected in the surfactant market. In terms of non-ionic surfactant AEO9, the market price in South China in early July 2026 was in the range of 12400-12600 yuan/ton, a decrease of about 400 yuan/ton compared to the end of May. The overall market presents a pattern of "cost support and weak demand tug of war" - the raw material side of ethylene oxide and fatty alcohols remains stable, but downstream industries such as daily chemical and textile industries generally have low acceptance of high priced raw materials and insufficient willingness to purchase at the end. In terms of anionic surfactant AES, the market price first rose and then fell in April 2026- at the beginning of the month, it hit a new high in recent years due to cost push. In the middle and late of the month, with the decline in raw material prices and poor transmission from the demand side, the price fell from the high point and remained weak and volatile until the end of the month. The mainstream quotation in the South China market at the end of April was in the range of 11900-12100 yuan/ton. 3.Industry pattern: Functional raw materials enter the capital market, quality competition replaces price war On August 11, 2026, Jiakai Biotechnology, a cosmetic efficacy ingredient company, was listed on the Beijing Stock Exchange. Our clients cover top brands such as Huaxi Biology and L'Oreal. On the first day of listing, the opening price increased by as much as 216.46%. It reflects a larger trend: the daily chemical raw material industry is shifting from simple price competition to comprehensive competition in quality and technology. Downstream purchasers are no longer solely concerned with unit price - batch stability of raw materials, compatibility of formulas, and supplier's technical service capabilities are becoming more important decision-making factors than price. The industry is transitioning from a "raw material supply" model to a "raw material supply+technological empowerment" model. There is still overcapacity and fierce price competition in the low-end general raw material field; And those raw material enterprises that can provide high quality, high stability, and technological added value are gaining more market discourse power. 4.New Desheng's layout of daily chemical raw materials Hubei Xindesheng Material Technology Co., Ltd. has been deeply engaged in the fields of fine chemicals and biological raw materials for more than 20 years, with product lines covering IVD diagnostic raw materials and daily chemical cosmetics raw materials. In 2026, the company was selected as a single champion enterprise in the manufacturing industry in Hubei Province. In the field of daily chemical and cosmetics, Xindesheng has formed multiple core product lines: Carbopol series: covering multiple models such as Carbopol 940, 980, etc., it is an excellent suspension agent, stabilizer, emulsifier, and water-soluble thickener. As carrier matrix in cosmetics, it is widely used in cream, gel, lotion, facial mask, shampoo, shower gel and other products. Carbopol can achieve effective emulsification at ultra-low concentrations of 0.1% -0.5%. At the same time, it can be used for washing free alcohol gel and other daily chemical products as thickening and gel forming agent. Biological buffer series: Tris (trihydroxymethyl aminomethane) is mainly used as a pH regulator and neutralizer in cosmetics, used to neutralize the thickener Carbopol and reduce stickiness; HEPES has become a new favorite in the cosmetics industry in recent years, which can adjust the pH value of cosmetics, reduce irritation, soften the stratum corneum, promote cell metabolism, and also have a penetration promoting effect. HEPES is used in some well-known products. EDTA series: EDTA dipotassium and EDTA disodium are chelating agents widely used in cosmetics. They can combine metal ions to prevent cosmetics from deteriorating, maintain product transparency, protect essence compounds, and prevent rancidity. Widely used in moisturizers, skincare products, and cleaning products. Makeup grade heparin sodium: has been included in the "Catalogue of Used Cosmetic Ingredients (2021 Edition)". Heparin sodium can increase skin vascular permeability, improve local microcirculation, promote skin nutrition supply and metabolic waste excretion, and have a good health effect on the skin. Used in cosmetics for removing dark circles, eye bags, fading, anti-aging, whitening, sun protection, and post sun care products. In terms of compliance, Xindesheng's daily chemical raw material products already have a raw material submission code - this is an identification code obtained by raw material enterprises after submitting raw material information on the cosmetics regulatory platform, which is used to associate raw material information during filing. Although the mandatory filling requirement for raw material submission codes has been abolished in the cosmetics registration and filing reform since July 1, 2026, the company has previously completed the systematic filing and archiving of raw material information, established a sound raw material quality file system, and can provide customers with complete compliance support. The rise in crude oil prices, fluctuations in surface activity, and the listing of functional raw materials - the daily chemical raw material industry is undergoing a deep reshuffle in 2026. Cost pressures are accelerating the elimination of inefficient production capacity, capital markets are opening their doors to companies with technological capabilities, and downstream customers are increasingly valuing quality and stability when choosing suppliers. For Xindesheng, with over 20 years of accumulation in the fields of fine chemicals and biomaterials - from Carbopol to Tris, HEPES, from EDTA to makeup grade heparin sodium - we will continue to serve every partner in the daily chemical and cosmetics industry with solid product strength, stable supply capacity, and comprehensive compliance support. Hubei Xindesheng Material Technology Co., Ltd. - Focusing on fine chemical and biological raw materials, helping daily chemical and precision diagnosis

In the summer of 2026, the global coatings industry will undergo a profound reshaping of its landscape. On July 1st, the former BASF Coatings Business Unit officially began independent operations in M ü nster, Germany under the new brand "Surventis". This independent enterprise with annual sales of approximately 3.9 billion euros, approximately 10700 employees, and a global layout of more than 30 production and research and development bases has become one of the world's leading suppliers of automotive coatings and surface treatment solutions. 1.Giant turns around: BASF Coatings becomes independent, Chinese entities intensively rename This spin off stems from a heavyweight transaction between BASF, Carlyle Fund, and Qatar Investment Authority, with a corporate value of up to 7.7 billion euros. After the transaction is completed, BASF holds 40% of the equity in Svetu, while Carlyle's funds and Qatar Investment Authority jointly hold 60%. At the same time as the equity delivery, several operating entities of Svetu in China are intensively promoting industrial and commercial name changes. Companies such as BASF Coatings Technology (Shanghai), BASF Coatings (Guangdong), BASF Shanghai Coatings (established in 1995 with a registered capital of approximately 609 million yuan), BASF (Shanghai) Coatings Manufacturing, and BASF Coatings (Changchun) have successively completed name changes. Changchun Company mainly serves northern car companies such as FAW Volkswagen and FAW Toyota, while Guangdong Company radiates to the southern Chinese market. A series of changes signify the accelerated formation of the operational framework for Svetu China. 2.Intelligent breakthrough: Svetu collaborates with domestic robots to deeply integrate technology and equipment After leaving the BASF brand endorsement, Svetu is seeking new growth paths, and intelligent cross-border cooperation has become an important lever. On August 13th, Svetu signed a strategic cooperation agreement with Dalian Nasida Automotive Equipment Co., Ltd., a core enterprise in domestic automotive spraying robots. Both parties are jointly promoting the process adaptation and iteration of the new generation of embodied intelligent spraying robots around the theme of "collaboration between materials and robots, integration of processes and equipment". Dalian Nasida has been deeply involved in the field of automotive after-sales equipment for 20 years and is the "hidden champion" in the domestic automotive maintenance equipment industry. According to the cooperation plan, both parties will achieve material process definition, equipment parameters, and intelligent equipment landing process standards. Relying on the AI driven operation system of Dalian Nasida, the robot completes the 3D modeling of the vehicle body through a 3D camera and automatically generates standardized spraying trajectories; Sviatu outputs a parrot (Glasurit) ®) High performance coating systems and precise color matching technology provide material and process standard support for robot operations. Industry data shows that the global market size for complete sets of automatic spraying robot systems will reach 4.6 billion US dollars by 2025, and is expected to grow to 11.15 billion US dollars by 2032. 3.New Desheng's perspective: Upgrading high-end coatings brings new opportunities for upstream raw materials The independent operation and intelligent transformation of Svetu reflect the profound changes that the coating industry is undergoing - from traditional manual spraying to intelligent and automated upgrades, and from solvent based coatings to water-based and environmentally friendly coatings. This trend places higher demands on the performance of coatings themselves, and also means that the value of upstream functional raw materials is being reassessed. Hubei Xindesheng Material Technology Co., Ltd. has been deeply engaged in the fields of fine chemicals and biological raw materials for more than 20 years. In 2026, it was selected as a single champion enterprise in the manufacturing industry of Hubei Province. The company has formed a multidimensional layout in the upstream raw material link of the coating industry: Carbopol series: As an efficient water-soluble rheological modifier, Carbopol has excellent thickening, suspension, and film-forming properties. Carbopol, as a thickener in coating formulations, can effectively regulate the rheological properties of coatings, improve construction performance, and is widely used in water-based coatings, architectural coatings, and other product systems. Tris (tris hydroxymethyl aminomethane): Tris is a weakly basic organic polyol containing trihydroxy and amino groups, which is suitable for water-based coatings, polyurethane coatings, polyester coatings, and functional building coatings. It has multiple functions such as pH buffering adjustment, cross-linking promotion, and dispersion stability in coatings. Its pKa ≈ 8.1, buffer range pH 7.0 – 9.2, accurately adapt to the stability range of water-based acrylic acid, polyurethane, lotion coatings. Tris can also be used as a polyol monomer in the synthesis of polyester and polyurethane resins, endowing coatings with high weather resistance and corrosion resistance. Compared to traditional ammonia and organic amines, Tris has lower volatility, fewer VOCs, and stronger environmental friendliness. CAPS (3- (cyclohexylamine) -1-propanesulfonic acid): CAPS is widely used in the coatings industry and can be used for modifying water-based isocyanate curing agents. CAPS contains sulfonic acid groups, which can adjust the pH value of the coating while increasing its hydrophilicity, helping to prepare more stable and environmentally friendly new water-based coatings. The polyisocyanate modified by CAPS has excellent storage stability and can be used to prepare environmentally friendly high-quality water-based two-component polyurethane coatings. The independent spin off of BASF's coatings business, the official operation of the Svetu brand, the intensive renaming of its entities in China, and the deep cooperation with domestic intelligent equipment enterprises - these series of events mark a new stage of development for the global coatings industry. Intelligence, automation, and environmental friendliness are becoming the core directions for upgrading coating technology. In this process, the requirements for the quality and stability of functional raw materials in coating formulations continue to increase. From the rheological regulation of Carbopol, to the pH buffering and cross-linking promotion of Tris, to the water-based curing agent modification of CAPS - Xindesheng's raw material products are providing key support for the technological upgrade of high-end coatings. We will continue to serve every partner in the paint industry with solid product strength and stable supply capability. Hubei Xindesheng Material Technology Co., Ltd. - Focusing on fine chemical and biological raw materials, assisting in coatings and precise diagnosis