Wuhan Desheng Biochemical Technology Co., Ltd

In the fields of chemical, daily chemical, and industrial production, finding a raw material that combines efficient dissolution, strong chelating ability, and pH adjustment function is the key to improving product stability and reducing costs. Tetrapotassium EDTA, with its ultra-high solubility, strong alkalinity, and potent chelating properties, has become a "versatile" in many industries. Its value is being recognized by more enterprises, from laboratory mother liquor preparation to daily chemical product formula optimization. 1, Ultra high solubility: efficient configuration, worry free production The solubility of tetrapotassium EDTA is as high as ≥ 1500g/L, which gives it a significant advantage in the solution preparation process. Traditional chelating agents often cause uneven concentration of mother liquor, equipment blockage, and even affect subsequent production processes due to slow dissolution rates or residual issues. And EDTA tetrapotassium can achieve "instant dissolution without residue", even under high concentration preparation requirements, it can quickly form a uniform solution, greatly reducing preparation time. For production enterprises, this characteristic directly translates into efficiency improvement: there is no need to repeatedly stir or heat dissolve, reducing labor and energy consumption; High concentration mother liquor can be diluted as needed to avoid frequent replacement of raw materials and reduce storage costs; The residue free characteristic can better protect equipment pipelines, extend their service life, and reduce the risk of downtime and maintenance caused by blockage. Whether it is large-scale industrial production or small-scale laboratory preparation, the "ease of use" of EDTA potassium has become a key factor in improving production smoothness. 2, Strong alkalinity (pH 11-12): dual-use, cost optimization The pH value of a 1% aqueous solution of potassium EDTA reaches 11-12, which gives it unique value in the fields of daily chemical and cleaning due to its strong alkaline properties. In traditional formulas, chelating agents and alkaline modulators often need to be added separately, which not only increases the variety of raw materials but also increases the complexity of the formula. The "alkaline+chelating" dual function of EDTA tetrapotassium can simultaneously accomplish two tasks: In cleaning agents, their strong alkalinity can effectively decompose stubborn stains such as oil stains and soap deposits, while chelating calcium and magnesium ions in water to prevent hard water from interfering with the cleaning effect and improve the cleaning power; In daily chemical products such as shampoo and shower gel, EDTA tetrapotassium can chelate metal ions to prevent formula oxidation and discoloration, while adjusting pH to an appropriate range to reduce skin irritation and enhance product mildness. For formulators, the "dual-use" of EDTA tetrapotassium means reducing the procurement and addition steps of at least one raw material, simplifying supply chain management; For production enterprises, formula optimization directly reduces raw material costs and production energy consumption, and enhances product market competitiveness. 3, Strong chelation: Stability guardian, quality assurance The core value of EDTA tetrapotassium lies in its strong chelating ability, which can firmly bind various metal ions such as Ca ² ⁺, Mg ² ⁺, Fe ² ⁺/³ ⁺, etc. Metal ions are "invisible killers" that cause product deterioration, precipitation, oxidation, or efficiency decline - for example, calcium and magnesium ions in water can react with soap to form soap deposits, reducing cleaning effectiveness; Iron ions can catalyze the oxidation of oils and fats, causing food or cosmetics to become rancid and discolored. EDTA tetrapotassium "locks" these metal ions to form stable chelates, blocking their participation in adverse reactions from the source: in the food industry, it can extend shelf life and prevent discoloration and flavor change; In cosmetics, formula stability can be maintained to avoid layering or precipitation; In industrial water treatment, it can prevent the deposition of metal ions and protect equipment from corrosion. Since its establishment in 2005, Hubei Xindesheng has been deeply engaged in the field of biochemistry for 20 years, accumulating rich experience in product production and use. At present, our carefully crafted EDTA tetrapotassium has a wide range of applications, high purity, and can meet various usage scenarios. At the same time, the company has a large-scale production base with strong production capacity. Whether you want to experience quality in small quantities or meet production needs through large-scale procurement, we can provide timely supply. If you are interested in our products, please feel free to call us for consultation and ordering at any time, and start a new chapter of cooperation and win-win!  

In the field of medical testing, the quality of separating gel collection tubes directly affects the serum separation efficiency and detection accuracy. This article will systematically review the entire process of adding glue to the separation glue collection tube, from the amount of glue used, operational skills to special scenario handling, providing practical guidance for production personnel. Glue dosage and thickness control: precise proportioning is the foundation The gluing process must strictly follow the corresponding standards for pipe diameter and dosage: Φ 13mm pipe diameter: It is recommended to add 0.8-1g of adhesive to ensure that the adhesive layer thickness reaches 6mm; Φ 16mm pipe diameter: It is recommended to add 1.4-1.6g of adhesive, and also ensure a thickness of 6mm. Insufficient thickness of the adhesive layer can lead to mixing of serum and blood cells, affecting the detection results; Excess may increase production costs. In practical operation, precise control can be achieved through colloid filling equipment. If there are doubts about the dosage, sales personnel can be contacted for personalized solutions. Winter gluing: temperature management is key Under low temperature conditions, the separation gel is prone to difficult flipping due to hardening, which affects the quality of serum separation. To address this issue, the following measures need to be taken: Natural temperature recovery: After transferring the colloid from outdoors to a 25 ℃ laboratory, let it stand for 30 minutes to 1 hour until the colloid softens before operation; Water bath heating: If rapid heating is required, the colloid can be heated in a 25 ℃ water bath (not exceeding 4 hours) to promote the recovery of colloid fluidity. By regulating the temperature, it is possible to effectively avoid the problem of poor flipping caused by colloidal hardness, ensuring the efficiency of serum separation. Laboratory gluing: strategies for addressing wire drawing issues If there is a wire drawing phenomenon during the gluing process, it not only affects the operational efficiency, but also may contaminate the blood collection tube.  The solution is as follows: 1. Water bath pretreatment: Heat the colloid in a 25 ℃ water bath (not exceeding 4 hours) to reduce its viscosity; 2. Equipment debugging: Check whether the nozzle of the filling equipment is blocked or worn, and replace the accessories in a timely manner; 3. Operation optimization: Keep the test tube vertical when adding glue, control the filling speed, and avoid excessive friction between the glue and the tube wall. Static storage and transportation after adding glue: details determine success or failure After adding the adhesive, it needs to be left vertically for 1-3 minutes to restore the thixotropy of the colloid and form a stable adhesive layer. Then, it should be placed flat and enter the next process. During the subsequent production and storage process, attention should be paid to: Avoid continuous flat placement: Prolonged flat placement may cause colloid flow, affecting the separation effect; Prevent inversion: Inverting can cause the colloid to come into contact with the pipe plug, increasing the risk of contamination; Standard stacking: Use dedicated trays or brackets to fix test tubes and maintain a vertical position. Bubble elimination: centrifugal process optimization Bubbles are a common issue that affects the quality of blood collection tubes and need to be treated through centrifugation technology Centrifuge after vacuum plugging: It is recommended to leave the plug for 24 hours before centrifuging and packaging to ensure that the bubbles are fully visible; Avoid centrifugation before plugging: Pre plugging centrifugation may cause colloidal displacement. It is recommended to check for bubbles 24 hours after plugging and re centrifuge if necessary; Equipment selection: Prioritize the use of inclined centrifuges to improve defoaming efficiency. If the blood collection tube needs to be sterilized by irradiation, the dose of cobalt 60 should be controlled to be ≤ 25kGy to avoid damage to the colloidal properties. Hubei Xindesheng Material Technology Co., Ltd., as a professional enterprise in the field of blood collection tube additives such as serum separation gel, has always been committed to providing customers with high-quality products and comprehensive services. We not only have high-quality serum separation gel products, but also a full range of blood collection tube additives such as anticoagulants, coagulants, silicides, etc. If you have any related procurement needs in the near future, please click on the official website to learn more details!      

Accurate measurement of blood calcium levels is crucial for disease diagnosis and treatment monitoring in clinical testing. However, traditional heparin lithium anticoagulants may interfere with calcium ion detection, leading to biased results. The heparin lithium zinc anticoagulant tube, through innovative formula design, effectively eliminates interference from free calcium and total calcium detection, while maintaining the stability of electrolyte measurement, making it the preferred tool for departments such as endocrinology and nephrology. 1, Formula innovation: Zinc ions replace calcium, precise anticoagulation without interference Free calcium detection without interference: Conventional heparin lithium anticoagulants may affect free calcium determination by binding to calcium ions, while zinc ions in heparin lithium zinc will preferentially occupy the binding sites of heparin, blocking the binding between heparin and calcium ions, thereby avoiding interference with free calcium detection. The principle is similar to "occupancy competition", which ensures the free form of calcium ions through the active binding of zinc ions, resulting in a more realistic physiological state. Total calcium detection without interference: Total calcium measurement needs to cover all forms of calcium (free calcium+bound calcium). Traditional anticoagulant tubes containing calcium ions (such as sodium citrate) will directly increase the total calcium content of the sample, resulting in inflated results. Heparin lithium zinc avoids the introduction of exogenous calcium from the source by adding zinc ions instead of calcium ions, ensuring that the total calcium measurement results only reflect the sample's own calcium content, significantly improving accuracy. 2, Electrolyte compatibility: a reliable guarantee for synchronous detection of multiple indicators In addition to calcium ions, clinical testing often requires simultaneous detection of electrolytes such as sodium (NaE) and potassium (K). Heparin lithium zinc anticoagulant tubes also perform well in this regard: Stable detection of sodium and potassium: The addition of zinc ions does not affect the concentration of sodium and potassium ions in the sample, and the detection results are highly consistent with the true values, meeting the clinical demand for synchronous analysis of multiple electrolytes. Avoiding cross interference: Traditional anticoagulants may cause cross interference between electrolytes due to their complex composition (such as the chelation of EDTA), while the formula of heparin lithium zinc is simple, containing only heparin lithium and zinc ions, minimizing the potential impact of non target components on detection. 3, Clinical application scenario: the preferred choice for departments with precise calcium demand measurement Based on the above advantages, heparin lithium zinc anticoagulant tubes have irreplaceable value in the following scenarios: Multi indicator joint detection: When the sample needs to be tested for total calcium, free calcium, sodium, potassium and other indicators simultaneously, heparin lithium zinc can complete anticoagulation in one go, avoiding sample waste or operational complexity caused by changing anticoagulants. For example, in emergency intensive care, obtaining comprehensive electrolyte and calcium metabolism data quickly is crucial for the treatment of critically ill patients. Endocrinology application: Patients with hyperparathyroidism or hypoparathyroidism need to frequently monitor blood calcium and parathyroid hormone (PTH) levels. Heparin lithium zinc anticoagulant tubes can ensure the accuracy of total calcium detection, providing reliable basis for disease diagnosis and efficacy evaluation. Application in Nephrology: Chronic kidney disease patients often have calcium and phosphorus metabolism disorders, and long-term monitoring of blood calcium, blood phosphorus, and electrolyte levels is required. The non-interference properties of heparin lithium zinc anticoagulant tubes can help doctors more accurately assess patients' metabolic status and adjust treatment plans. Hubei Xindesheng is a professional manufacturer of blood collection tube additives. Since its establishment in 2005, it has accumulated 20 years of experience in research and development, production, and use. The company can provide more than ten types of blood collection tube additives, including heparin lithium zinc, heparin lithium, heparin sodium, etc., with a wide range of types and applications. If you have any related needs, please feel free to inquire and place an order at any time. We look forward to working together with you!  

In the field of medical testing, separating gel collection tubes is an important tool for sample collection and preservation, and its quality directly affects the accuracy of the test results. However, in actual production and application, the problem of bubbles in serum separation gel often occurs, becoming a major hidden danger affecting product quality. This article will deeply analyze the reasons for the generation of bubbles in separation glue from two aspects: production and processing technology and raw materials, and propose corresponding solutions. The hidden danger of bubbles in production and processing technology 1. Bubbles mixed in during the gluing process Adding glue is the first step in the production of separated glue collection tubes, and it is also the stage where bubbles are most easily mixed in. During the gluing process, due to improper operation or equipment limitations, air may inadvertently mix into the separation glue. These small bubbles are often difficult to detect in their initial state and almost indistinguishable to the naked eye. However, when negative pressure is applied to the blood collection tube, the pressure difference between the inside and outside increases, and the originally small bubbles gradually expand and grow until they reach an observable level. At this point, people often mistakenly believe that bubbles are "regenerated", but in fact, these bubbles have existed since the addition of glue, but have not been discovered due to their small volume. Solution strategy: In response to the problem of bubbles during the gluing process, enterprises should optimize the gluing process, adopt advanced gluing equipment, ensure a smooth and continuous gluing process, and reduce the chance of air mixing. At the same time, strengthen the control of the production environment, maintain the cleanliness and dryness of the production area, reduce the content of dust and moisture in the air, and further reduce the possibility of bubble generation. Bubble formation during irradiation sterilization process Radiation sterilization is an indispensable part of the production of separated rubber blood collection tubes, which uses the energy released by electron beams or gamma rays to kill microorganisms and ensure the sterile state of the product. However, the amount of energy released during the irradiation process, i.e. the irradiation dose, directly determines the sterilization effect and stability of the product. Insufficient irradiation dose may lead to incomplete sterilization; Excessive irradiation dose may cause damage to the product structure, such as cross-linking and curing, while releasing a large amount of heat energy. If these heat sources are not eliminated in a timely manner, bubbles will form inside the product. Solution strategy: In response to the bubble problem during irradiation sterilization, enterprises should strictly control the irradiation dose, accurately calculate and set appropriate irradiation parameters based on the characteristics of the product and sterilization requirements. At the same time, optimize the cooling system of the irradiation equipment to ensure that the generated heat can be promptly dissipated during the irradiation process, avoiding bubbling caused by heat accumulation. In addition, regular maintenance and calibration of irradiation equipment to ensure it is in optimal working condition is also an effective means of reducing bubble generation. 2, The influence of raw material selection on bubbles In addition to production and processing technology, the selection of raw materials is also an important factor affecting the generation of bubbles in the separation gel. High quality raw materials are the foundation for producing high-quality separation adhesives. If there are impurities or moisture in the raw materials, these impurities may become nucleation sites for bubbles during the gluing or irradiation process, promoting the formation and expansion of bubbles. Therefore, when selecting raw materials, enterprises should strictly control the quality to ensure that the purity and quality of the raw materials meet the production requirements. Hubei Xindesheng Material Technology Co., Ltd., as a professional enterprise in the field of blood collection tube additives such as serum separation gel, has always been committed to providing customers with high-quality products and comprehensive services. We not only have high-quality serum separation gel products, but also a full range of blood collection tube additives such as anticoagulants, coagulants, silicides, etc. If you have any related procurement needs in the near future, please click on the official website to learn more details!