How To Understand The Anhydrous Potency Of Heparin Lithium 9045-22-1

In the field of modern medicine, lithium heparin is an important anticoagulant drug widely used in clinical diagnosis and treatment. Its unique anticoagulant properties make heparin lithium occupy an important position in multiple medical fields such as hematology and cardiovascular disease. The anhydrous potency of lithium heparin, as an important indicator for measuring its anticoagulant ability, has attracted much attention. This article will delve into the basic properties, definition of anhydrous potency, determination methods, and application value of lithium heparin.

Basic properties of lithium heparin

Heparin lithium is a white amorphous powder, odorless, easily soluble in water and hygroscopic, with an average molecular weight of 15000 and stable properties at room temperature. As a salt form of heparin, it exerts anticoagulant effects. Its anticoagulant mechanism mainly enhances the activity of antithrombin, inhibits the generation and activity of thrombin, and thus blocks the progress of coagulation reaction.

lithium heparin powder

Definition of anhydrous potency

Anhydrous potency, as the name suggests, refers to the anticoagulant efficacy unit exhibited by heparin lithium in an anhydrous state. Specifically, it reflects the strength of the anticoagulant effect of lithium heparin per unit mass in a water free environment on blood. The level of anhydrous potency directly determines the anticoagulant effect of heparin lithium products and is one of the key indicators for evaluating their quality.

Method for determining anhydrous potency

Due to the fact that the potency of heparin products cannot be accurately determined by chemical or physical methods, biological assays are usually used to determine their anhydrous potency. Biological assay is a method of determining the potency and biological activity of drugs by comparing their effects on living organisms with standard samples. In the determination of the anhydrous potency of heparin lithium, plasma method and chromogenic substrate method are mainly used.

1. Plasma method

Although the plasma method can comprehensively measure the anticoagulant activity of heparin, it is limited in practical applications due to its complex operation and difficulty in standardization. This method calculates the anhydrous potency by comparing the changes in clotting time caused by heparin lithium samples and standards in plasma.

2. Chromogenic substrate method

The chromogenic substrate method is currently a commonly used international method for determining the potency of heparin. This method uses an enzyme-linked immunosorbent assay (ELISA) reader to read the colorimetric reaction of heparin sodium standard and test sample against IIa and Xa factors at a specific wavelength, and calculates the anhydrous potency by comparing the absorbance values of the two. The chromogenic substrate method has high specificity and can identify potential heparin like drugs that cannot be identified by traditional plasma methods. It is also easy to achieve automation and standardization.

The application value of anhydrous potency

The anhydrous potency, as an important indicator for quality control of heparin lithium products, is of great significance in ensuring product stability and efficacy. High anhydrous potency heparin lithium products can more effectively exert anticoagulant effects, reduce dose fluctuations and adverse reactions in clinical use.

Product packaging

Hubei Xindesheng Material Technology Co., Ltd. specializes in the research and development of heparin lithium and other blood collection tube additives. Currently, the conventional heparin lithium on sale has a potency of 150IU/mg and an anhydrous potency of 160IU/mg. Our professional technical team and advanced research and development equipment can also provide customized services according to customer needs. Desheng is one of the few high-quality manufacturers in China that can provide a full range of blood collection tube additives. With extensive experience in research and development, production, and sales, we are committed to providing customers with excellent service. If you have any purchasing needs in the near future, please click on the official website for more details or contact me!