Analysis of Aging Phenomenon of Serum Separation Gel and Corresponding Strategies

In medical laboratories and clinical diagnosis, serum separation gel is widely used as an important auxiliary material for rapid separation of serum and blood cells. However, over time, serum separation gel may experience aging, which not only affects its separation efficiency but may also have adverse effects on experimental results. This article will explore the aging phenomenon of serum separation gel from multiple aspects and propose corresponding countermeasures.

Appearance changes of serum separation gel aging

After aging, serum separation gel may undergo some changes in appearance. Serum separation gel without aging is usually transparent, semi transparent, or opaque, with a uniform color and texture. However, as the degree of aging deepens, the separation gel may exhibit phenomena such as darkening of color, turbidity, generation of bubbles or granular substances. These changes may be caused by the degradation, oxidation, or microbial contamination of certain components in the separation gel.

serum separation gel

Decreased separation effect

The main function of serum separation gel is to quickly separate serum from blood cells and extract high-quality serum samples. However, the aging serum separation gel cannot maintain good thixotropy and cannot form a good barrier after centrifugation, resulting in a significant decrease in its separation effect. It cannot effectively separate serum and blood clots, leading to the inclusion of blood cell components in the serum, which affects the accuracy of subsequent experiments.

The impact on experimental results

The impact of aging of serum separation gel on experimental results cannot be ignored. Due to the decreased separation effect of aging separation gel, the purity of extracted serum samples may decrease, which may lead to bias or errors in experimental results. Therefore, when using aged serum separation gel for experiments, it is necessary to carefully evaluate its impact on the experimental results.

Analysis of aging causes

1. Improper storage conditions: Serum separation gel should be stored in a dry, cool, and dark environment. If the storage temperature is too high, humidity is too high, or exposed to direct sunlight, it will accelerate the aging process of the separation adhesive.

2. Repeated freeze-thaw: During the repeated freeze-thaw process, the structure of serum separation gel is easily damaged, leading to accelerated aging.

3. Microbial contamination: If serum separation gel is contaminated by microorganisms during preparation or storage, it will accelerate its degradation and aging process.

Strategies and Suggestions for Response

We can take the following measures and suggestions to address the aging issue of serum separation gel:

1. Strict storage management: Ensure that the serum separation gel is stored in a dry, cool, and dark environment, and regularly check whether the storage conditions meet the requirements.

2. Avoid repeated freeze-thaw cycles: Try to reduce the number of freeze-thaw cycles of serum separation gel. If it needs to be used multiple times, it can be stored in separate packages.

3. Strict quality control: When preparing and using serum separation gel, relevant standards and operating procedures should be strictly followed to ensure its quality meets the requirements.

4. Choose high-quality products: When purchasing serum separation gel, it is important to choose a reputable and reliable product supplier to ensure that the purchased separation gel has good performance and stability.

packing of products

Hubei Xindesheng Material Technology Co., Ltd., as a manufacturer of blood collection additives such as serum separation gel, has a good reputation in China. Rich R&D and production experience, professional laboratory equipment and technical personnel can provide good customization and after-sales service while ensuring product quality. Interested parties are welcome to click on the official website to learn more details!