Wuhan Desheng Biochemical Technology Co., Ltd

Serum separation gel is a key material for achieving physical isolation between serum and blood cells in blood collection vessels. In actual production, the amount and operation process of separation gel directly affect the separation effect and stability of blood collection tubes. Different specifications of blood collection tubes correspond to different amounts of additives, and there are clear sequential requirements for the processing steps after adding glue. The dosage of separation gel for different specifications of blood collection tubes There are various sizes of blood collection tubes, ranging from 2 milliliters to 9 milliliters, with tube diameters of 13 millimeters and 16 millimeters. The amount of separation gel added is not strictly proportional to the volume of the blood collection tube. The blood collection tubes of 2ml, 3ml, and 4ml sizes all use 13 × 75mm tubes, and the amount of separation gel added is 0.8g. The 5ml and 6ml specifications use 13 × 100mm tubes with the same addition amount of 0.8g. The 9ml specification uses a 16 × 100mm tube body, and the addition amount is increased to 1g. From these data, it can be seen that for a tube with a diameter of 13 millimeters, whether the volume is 2 milliliters or 6 milliliters, the addition of 0.8 grams of separation gel can basically meet the usage requirements. The key is that the final thickness of the separation adhesive layer needs to reach 6 millimeters, which is the minimum requirement for effective isolation. Regardless of the total volume of the blood collection tube, the separation gel after centrifugation should form a continuous barrier of sufficient thickness between serum and blood cells to prevent the exchange of substances between the two sides. Process flow after adding separation adhesive The addition of separation gel is not the final step in the production of blood collection tubes, there are multiple processing steps that follow. The standard procedure is to add glue first, and then leave it for 24 hours. The purpose of this static step is to ensure that the separation glue is fully leveled and stable at the bottom of the tube, eliminating internal stress or uneven distribution generated during the gluing process. After placement, add the coagulant. The function of coagulants is to accelerate the coagulation process after blood collection and shorten the sample processing time. After adding the coagulant, a drying operation is required to remove excess moisture from the tube. Subsequently, vacuum is applied to create a negative pressure environment inside the blood collection tube, which facilitates the automatic flow of blood into the tube during blood collection. Finally, there is the packaging process. The produced blood collection tubes need to undergo centrifugation validation during use, with centrifugation parameters generally set at 3000 revolutions per minute for 15 minutes. Under these conditions, the separation gel should be able to migrate smoothly between serum and blood cells, forming a complete isolation layer. The core use of separation glue The main function of serum separation gel is to form an isolation layer between the cellular components of blood and serum. This physical barrier can prevent the exchange of substances between blood cells and serum, including the diffusion of potassium ions, enzymes, and other components from blood cells into serum, as well as the absorption of certain components in serum by blood cells. By preventing these exchanges, the separation gel ensures that the blood sample maintains its original characteristics for a certain period of time, making the test results more accurate and reliable. At present, the application scenario of separation gel is mainly for the examination of human blood samples. Meanwhile, with the development of veterinary testing and animal experiments, separation gels have also been used for the extraction and examination of animal blood samples. In addition, by utilizing the precise specific gravity characteristics of the separation gel, various specific cellular components or analytes can be extracted from the blood. Hubei Xindesheng Material Technology Co., Ltd. has been deeply involved in the field of serum separation gel for many years. With professional research and strict production, we have created products with excellent performance and stable quality. We always uphold a rigorous and responsible attitude, providing high-quality serum separation gel for the medical testing industry. Choosing Hubei Xindesheng means choosing a professional, stable, and reliable medical testing guarantee. If you have any purchasing needs in the near future, please click on the official website to learn more details!    

In the field of chemiluminescence immunoassay, selecting suitable luminescent substrates directly affects the performance and operational convenience of the detection system. Acridine esters are a class of chemiluminescent reagents that do not require enzyme catalysis and can directly emit light, similar to luminol AMPPD, Compared with substrates such as triphenylpyridine ruthenium, it exhibits unique advantages in terms of ease of operation, system stability, and cost of use. No catalyst needed: simplifying the reaction system Acridine esters (including acridine sulfonamide) can emit a light signal with a wavelength of 470 nanometers when oxidized by hydrogen peroxide under alkaline conditions. This luminescent process has high luminescence efficiency, and its excited state product N-methylacridone is the luminescent material of the reaction system. Acridine esters directly participate in luminescent reactions without the need for any enzyme catalysis. This characteristic brings about the simplification of the reaction system. In immunoassays, acridine esters can directly label antibodies, antigens, or magnetic beads. After an immune reaction occurs between the marker and the test sample, a solid-phase complex is formed. After rinsing, only hydrogen peroxide and sodium hydroxide need to be added to make the system alkaline, and the acridine ester will decompose and emit light. Throughout the process, there is no need to consider issues such as enzyme activity preservation, temperature adaptation range, and pH compatibility, making the operation steps more concise. Comparison with Enzymatic Luminescence System Luminol and AMPPD belong to enzymatic chemiluminescence substrates. Luminol requires catalysis by peroxidase (POD or HRP) to effectively emit light, while AMPPD requires catalysis by alkaline phosphatase. Due to the addition of enzymes in the reaction, the complexity of the system significantly increases. The activity of enzymes is greatly affected by temperature, and storage and transportation require cold chain protection; At the same time, the suitable pH range for enzymes may not fully match the optimal conditions for the protein to be labeled, and multiple factors need to be comprehensively balanced in formula development. In addition, enzymatic systems often require enhancers to enhance the luminescence signal, further increasing the composition and cost of the reagents. The acridine ester system does not involve enzymes, so the above problems do not exist. No need for enhancers means lower background luminescence and higher signal-to-noise ratio, fewer interference factors, and more reliable detection results. Comparison with electrochemiluminescence Tripyridine ruthenium belongs to electrochemiluminescence substrates. This type of system performs excellently in terms of detection speed, sensitivity, detection range, and precision. But its drawbacks are also quite obvious. In terms of instruments, electrochemiluminescence usually adopts a flow colorimetric cell design, which poses a potential risk of cross contamination. The price of testing instruments is relatively high, with relatively few domestic users and limited popularity. In addition, electrochemiluminescence systems are more sensitive to environmental factors and non-specific reactions, and have higher requirements for operating environment and reagent quality. The acridine ester system is based on the principle of ordinary chemiluminescence and does not require complex electrodes and electrochemical reaction cells. The instrument cost is much lower than that of electrochemiluminescence. At the same time, the use and research and development costs of reagents are also more advantageous, suitable for large-scale promotion and application in routine detection scenarios. comprehensive value The advantages of acridine ester luminescent agents are mainly reflected in the following aspects: no need for enzyme catalysis, no need for enhancers, low background luminescence, high signal-to-noise ratio, minimal interference, and controllable use and development costs. These characteristics make acridine esters a competitive choice in tubular chemiluminescence detection. Hubei Xindesheng Material Technology Co., Ltd. specializes in the production of chemiluminescence reagents. In addition to luminol reagents, the available acridine ester varieties include DMAE-NHS, Me DMAE-NHS, NSP-DMAE-NHS, NSP-SA-NHS, etc., which can meet the requirements of different labeling needs and detection platforms. If you have any purchasing needs in the near future, please feel free to consult me at any time!  

The quality of sea crystals is directly related to the health status of marine organisms in aquaculture and laboratory simulated seawater environments. Trace elements are key components in sea crystal formulas, but they are prone to hydrolysis, oxidation, or precipitation in aqueous solutions. BICINE buffer, as a zwitterionic buffer, is gradually becoming an effective tool to solve this problem. Stability challenges faced by trace elements Various trace elements such as iron, zinc, copper, manganese, and molybdenum need to be added to sea crystals. These elements exist at extremely low concentrations in natural seawater, but play a decisive role in algae growth, coral health, plankton reproduction, and juvenile development. However, when these metal ions are concentrated in liquid formulations, the environment becomes complex. Small fluctuations in pH can trigger hydrolysis reactions of metal ions, leading to their precipitation from the solution. In the presence of oxygen, certain elements undergo oxidation and transform into forms that cannot be utilized by living organisms. Traditional buffer systems such as phosphates or carbonates, although capable of regulating pH, are prone to form insoluble complexes with metal ions, which in turn reduces the bioavailability of trace elements. The buffering advantage of BICINE The effective buffering range of BICINE is between 7.6 and 9.0, which perfectly matches the pH range of natural seawater. This means that it can effectively suppress pH drift in dynamic environments, providing a relatively stable chemical environment for trace elements. More importantly, BICINE has a stable molecular structure and moderate coordination ability. It does not undergo strong interference reactions with metal ions like some traditional buffering agents, so it is not easy to cause precipitation or deactivation of trace elements. This moderate interaction ensures both buffering effect and long-term stability and efficient release of nutrients. Extend the shelf life of concentrated solution In the production and storage process of sea crystals, trace element concentrates often need to be stored for a long time before they can be used. This places high demands on the chemical stability of the formula. BICINE has good water solubility and can maintain molecular integrity in high ionic strength environments. In the concentrated solution system with BICINE added, the oxidation rate of iron ions is significantly reduced, the precipitation time of copper, zinc and other elements is delayed, and the overall solution can remain clear for a longer period of time. For sea crystal manufacturers, this means an extension of product shelf life and a reduction in customer complaints. Support the upgrading of scientific research and aquaculture In scientific research grade artificial seawater preparation, environmental repeatability is a prerequisite for obtaining reliable data. The low toxicity and high biological inertness of BICINE enable it to be safely applied in highly sensitive scenarios such as cell culture, marine microbial research, and embryo development experiments. When BICINE is used for sea crystal concentrate, it helps to create a chemical microenvironment closer to natural seawater, reducing experimental errors caused by pH fluctuations or metal deactivation. In the field of aquarium viewing, sea crystal products containing BICINE help prevent coral fading and algae imbalance, improving the survival rate and color expression of organisms. The actual effect of BICINE highly depends on the purity of the raw materials. The purity of BICINE and other biological buffering agents produced by Hubei Xindesheng Material Technology Co., Ltd. can reach over 99%, and heavy metal residues are controlled at extremely low levels. In addition, Desheng's strict quality control system ensures that each batch of products is highly consistent in buffering performance, dissolution rate, and chemical stability, providing reliable raw material guarantee for sea crystal manufacturers. If you have any recent purchasing needs, please click on the official website to learn more details!  

The 24th CPHI China 2026, together with the 19th PMEC China 2026, officially kicked off on June 16th at the Shanghai New International Expo Center. The exhibition will last for three days, with a display area of over 250000 square meters, gathering more than 3700 exhibitors from home and abroad, covering more than 180 countries and regions, and is expected to attract over 110000 professional visitors. Concentrated presentation of the entire industry chain ecosystem This exhibition has set up multiple special zones to comprehensively showcase the complete industry chain ecology from drug research and development, raw material production to formulation manufacturing, packaging and transportation. The cutting-edge technology and innovative achievements exhibition area of W9 Hall covers antibodies CGT, Innovative drug technology services such as peptides and nucleic acid drugs; The W16 Smart Laboratory space presents immersive real-life laboratory automation, intelligent sample processing, and other digital solutions. The traditional Chinese medicine and herbal medicine sections of Hall E5, the medical beauty packaging materials section of Hall E8, and the drug and equipment combination section of Hall N6 are simultaneously open, providing opportunities for audiences from different segmented fields to learn about industry trends. During the exhibition, multiple technical seminars and supply and demand matching activities were also held, covering hot topics such as biotechnology development, laboratory automation, and internationalization of active pharmaceutical ingredients. New Desheng booth communication heat rises Hubei Xindesheng Material Technology Co., Ltd. showcased its core product lineup at this exhibition, with its booth located in the IVD core raw material exhibition area. The company dispatched a professional team of 6 people to be stationed throughout the entire process, engaging in face-to-face communication with new and old customers from both domestic and overseas. Since its launch, the New Desheng booth has attracted numerous professional visitors to stop and inquire. Among the visiting clients are both long-term IVD reagent manufacturers, overseas buyers who have had their first contact with the company's products, and customer representatives from Southeast Asia, the Middle East, Europe, and other regions. The negotiation mainly focuses on the technical parameters, customized requirements, and supply chain guarantee of biological buffering agents (Tris base, HEPES, MOPS, PIPES, etc.), chemiluminescence reagents (luminol, isoluminol, acridine ester, etc.), chromogenic substrates, enzyme preparations, and blood collection tube additives. Huanggang new factory is about to start production, attracting attention Several customers have shown strong interest in the new production base of Hubei Xindesheng located in Huanggang. The new base will be officially put into operation in July 2026, with dozens of customized large-scale reaction vessels in place, greatly expanding the production capacity of biological buffering agents and IVD core raw materials. After production, the scale production capacity, raw material quality control level, and large-scale order delivery capability will achieve a leapfrog improvement, better responding to the continuously growing raw material demand in domestic and foreign markets. Many customers have had in-depth discussions with the team regarding the production capacity scale, product line expansion, and future supply stability of the new base, hoping to establish a closer cooperative relationship after the new factory is put into operation. Continuous communication cordially invites you to visit The exhibition is still in full swing and will continue until June 18th. As a professional supplier with nearly 20 years of deep cultivation in the field of IVD core raw materials, Hubei Xindesheng further demonstrated its research and development strength and production capacity layout in the fields of biological buffering agents and IVD core raw materials through this exhibition. The New Desheng team welcomes more industry colleagues to visit the booth for exchange and guidance. Whether it is IVD reagent manufacturers seeking stable supply or R&D personnel focusing on upstream raw material technology innovation, they can conduct in-depth discussions on product applications, technical difficulties, and cooperation models. New Desheng will continue to provide reliable upstream raw material solutions for the pharmaceutical and in vitro diagnostic industries.