Wuhan Desheng Biochemical Technology Co., Ltd

Fluttering banners, embarking on a new journey, fighting fiercely for a hundred days to see the true chapter In the summer of 2025, on the hot land of innovation and entrepreneurship in Huanggang, Hubei, a modern chemical plant representing a new height in the industry is rising at an astonishing speed. Since the foundation laying and departure on July 18th, the Huanggang new factory project of Hubei Xindesheng Material Technology Co., Ltd. has embarked on a construction journey of racing against time with the spirit of "time waits for no one, seize the day and night". In just two months, the project team has written an impressive report card with wisdom and sweat, perfectly interpreting the profound connotation of "Desheng efficiency" with tangible construction results, injecting a shot in the arm for local economic development. Warehouse sealing: Warehouse center takes shape first On September 14, 2025, the project construction once again reached a milestone moment - the main structure of Warehouse 3 successfully completed the topping out work! This advanced design and fully functional storage facility has completed the main construction first, which means that the construction of the new factory has achieved significant results in this stage. The topping out of the warehouse not only creates conditions for subsequent internal decoration and equipment installation, but also ensures the efficient operation of the future factory logistics and warehousing system. At the topping out ceremony, the project leader stated, "The rapid topping out of Warehouse 3 is a testament to our careful organization and scientific construction, and also a good start for the on-time delivery of the entire project. Multi line joint promotion: Comprehensive construction momentum is unstoppable At the same time, the construction of other key nodes in the new factory area is also progressing efficiently and synchronously, presenting a busy scene of multiple blooming points and simultaneous progress. The construction of the gutter and roof system in the 1 # production plant is in full swing, creating favorable conditions for the installation of internal equipment in the plant; The circulating water tank supporting the factory area has completed the base treatment and entered the plastering construction stage, and the bottom plate formwork construction of the base water tank and the initial rainwater tank has also been fully carried out. The synchronous construction of these supporting facilities ensures the coordinated operation of production and environmental protection systems in the future factory area, reflecting New Desheng's high emphasis on sustainable development. Strategic positioning: Building a domestic base for high-end biological buffering agents The Huanggang New Factory project is committed to building a domestic high-end biological buffer production base, focusing on breakthroughs in key preparation technologies for a series of high-end biological buffers such as TRIS, HEPES, MOPS, etc. By constructing multiple intelligent production lines, the project will achieve a significant increase in the production of high-end biological buffering agents after it is put into operation, and it is expected that the annual output value will achieve a leapfrog growth. The construction of this base will effectively break the technological and market monopoly of foreign manufacturers in the field of high-end biological buffering agents. Anchor new goals and embark on a new journey The rapid progress of Huanggang's new factory construction is not only an important milestone in the development history of Xindesheng, but also a microcosm of China's intelligent manufacturing speed. From a blueprint to the initial scale of the factory building, from the groundbreaking ceremony to the topping out of the warehouse, the early completion of every milestone embodies the wisdom and sweat of all builders, demonstrating the corporate spirit of "pioneering innovation and pursuing excellence" of Xindesheng people. With the continuous advancement of the project, it will undoubtedly inject strong impetus into the future development of Xindesheng and contribute important strength to the high-quality development of the local economy.

For a long time, some studies have assumed that Bicine cannot interact with metal ions. However, an increasing number of facts indicate that Bicine can form stable binary or ternary complexes with metal ions, exhibiting certain chelating properties. The molecular structure of Bicine buffer is similar to that of glycine. This structure reduces the hydrolysis ability of the amino end, enhances overall stability, and also creates conditions for its binding with metal ions. Research has shown that Bicine can chelate with heavy metal ions such as copper (Cu), cadmium (Cd), and lead (Pb). However, this chelation effect is relatively weak and does not significantly interfere with the normal function of metal ions in most biochemical reactions, especially enzymatic reactions. In enzymatic reactions, metal ions often act as cofactors or coenzymes in the catalytic process, and their activity is highly influenced by various factors, with pH being one of the key factors. Extreme pH values can alter the binding state between metal ions and enzymes, thereby affecting catalytic activity. Bicine maintains pH stability in the solution while having weak chelation effect on metal ions, making it an ideal choice for enzymatic reactions that require the retention of metal ion activity. For example, in the serum guanine enzyme assay, the presence of Bicine can provide a stable pH environment for enzymatic reactions, and due to its weak binding properties with metal ions, it will not interfere with the role of metal ions in the reaction, ensuring the accuracy of the measurement results. From an application perspective, this characteristic of Bicine enables it to be widely used in many fields. In protein crystallization solution, Bicine can maintain the pH stability of the system without affecting the necessary interactions between proteins and metal ions due to excessive chelation of metal ions, which is beneficial for the growth and stability of protein crystals. Bicine acts as a buffer when extracting enzymes from various plant species, ensuring a suitable pH environment and maintaining metal ions in a free state that can participate in the composition of enzyme active centers or promote enzyme activity. In polymerase chain reaction (PCR), Bicine buffer system provides stable acid-base conditions for the reaction, while not hindering the reaction due to strong chelation of metal ions (such as magnesium ions, activators of Taq DNA polymerase in PCR reaction). Overall, the weak binding properties of the biological buffer Bicine with metal ions have more advantages than disadvantages in most biochemical and molecular biology applications. It provides a stable and suitable environment for numerous biochemical reactions that require the participation of metal ions, ensuring the authenticity and reliability of experimental results. With the continuous deepening of research and the expansion of application fields, fully understanding and reasonably utilizing the characteristics of Bicine and metal ions will inject new vitality into the development of related fields. The Bicine buffer produced by Hubei Xindesheng Material Technology Co., Ltd. has a low chloride ion content and all indicators meet relevant standards. In addition to Bicine buffer, Desheng actively researches and develops dozens of biological buffers such as TRIS and Hepes commonly used in the market. If you are interested, please click on the Desheng official website to learn more details! Overall, the weak binding properties of the biological buffer Bicine with metal ions have more advantages than disadvantages in most biochemical and molecular biology applications. It provides a stable and suitable environment for numerous biochemical reactions that require the participation of metal ions, ensuring the authenticity and reliability of experimental results. With the continuous deepening of research and the expansion of application fields, fully understanding and reasonably utilizing the characteristics of Bicine and metal ions will inject new vitality into the development of related fields. The Bicine buffer produced by Hubei Xindesheng Material Technology Co., Ltd. has a low chloride ion content and all indicators meet relevant standards. In addition to Bicine buffer, Desheng actively researches and develops dozens of biological buffers such as TRIS and Hepes commonly used in the market. If you are interested, please click on the Desheng official website to learn more details!  

Currently, China's primary healthcare system is undergoing unprecedented transformation and upgrading, leading to explosive growth in the field of in vitro diagnostics (IVD). This trend was confirmed at the recent "Million Talents Gathering in Southern Guangdong" medical and health job fair: 334 employers offered more than 6500 positions, with a particularly prominent demand for professionals in imaging, anesthesia, and other fields in county-level medical institutions. It is worth noting that the development of these departments is closely related to IVD technology, reflecting the strong demand for diagnostic testing in primary healthcare. The deep driving force behind the surge in demand The sustained release of policy dividends is the primary driving force. With the support of national policies, the hardware facilities of grassroots medical institutions have been comprehensively upgraded, and modern diagnostic and treatment equipment has been installed in township health centers and village clinics. Hardware improvements have created conditions for carrying out diversified testing projects, while the demand for accurate diagnosis among grassroots doctors has also skyrocketed. The rapid detection technology represented by POCT can precisely meet the dual pursuit of timeliness and accuracy at the grassroots level. The demographic changes bring new challenges. Global data show that the incidence rate of invasive fungal disease is increasing at an annual rate of 0.9%, and the elderly, especially those with chronic diseases, become vulnerable. The early identification of such diseases at the grassroots level highly relies on IVD technologies such as fungal culture and G-testing, which requires primary healthcare institutions to enhance their diagnostic capabilities. The deepening implementation of the hierarchical diagnosis and treatment system reshapes the pattern of medical treatment. With the promotion of the policy of first diagnosis at the grassroots level, grassroots medical institutions need to establish a more comprehensive diagnostic system. Fast and reliable IVD testing can not only help doctors timely assess the condition, but also provide scientific basis for patient referrals, effectively improving the efficiency of medical resource utilization. The deep driving force behind the surge in demand The sustained release of policy dividends is the primary driving force. With the support of national policies, the hardware facilities of grassroots medical institutions have been comprehensively upgraded, and modern diagnostic and treatment equipment has been installed in township health centers and village clinics. Hardware improvements have created conditions for carrying out diversified testing projects, while the demand for accurate diagnosis among grassroots doctors has also skyrocketed. The rapid detection technology represented by POCT can precisely meet the dual pursuit of timeliness and accuracy at the grassroots level. The demographic changes bring new challenges. Global data show that the incidence rate of invasive fungal disease is increasing at an annual rate of 0.9%, and the elderly, especially those with chronic diseases, become vulnerable. The early identification of such diseases at the grassroots level highly relies on IVD technologies such as fungal culture and G-testing, which requires primary healthcare institutions to enhance their diagnostic capabilities. The deepening implementation of the hierarchical diagnosis and treatment system reshapes the pattern of medical treatment. With the promotion of the policy of first diagnosis at the grassroots level, grassroots medical institutions need to establish a more comprehensive diagnostic system. Fast and reliable IVD testing can not only help doctors timely assess the condition, but also provide scientific basis for patient referrals, effectively improving the efficiency of medical resource utilization. Future Prospects Despite challenges such as talent shortage and quality control, the grassroots IVD market has enormous potential driven by policy support and technological progress. It is expected that in the coming years, with the integration and application of new technologies such as telemedicine and artificial intelligence, grassroots diagnostic services will develop towards a more intelligent and accurate direction, providing strong support for the construction of a healthy China. After years of development, Hubei Xindesheng Material Technology will uphold innovative concepts, continuously improve product quality and service levels, and contribute to the development of the IVD industry.  

Acridine esters, as an important class of chemiluminescent reagents, are widely used in fields such as immunoassay, nucleic acid detection, and biosensors due to their high sensitivity, rapid luminescence, and low background interference. However, its unique chemical properties require strict adherence to specific specifications during the dissolution process, otherwise it may lead to reagent deactivation or experimental failure. This article will start from the preservation characteristics of acridine esters and systematically analyze their scientific dissolution methods and operational points. Preservation characteristics of acridine ester: necessity of freeze-dried powder and low-temperature light avoidance Acridine esters are typically provided in the form of freeze-dried powder, which is designed to inhibit hydrolysis reactions and prolong reagent stability by removing moisture. The freeze-drying process can remove over 95% of the moisture, keeping the acridine ester molecules in an inactive state while avoiding aggregation or degradation caused by the presence of moisture. In addition, low temperature (usually -20 ℃ or lower) and light avoidance conditions are key to preserving acridine esters: low temperature can slow down molecular thermal motion and reduce hydrolysis rate; Avoiding light can prevent structural damage caused by photosensitive reactions. For example, acridine esters containing NHS (N-hydroxysuccinimide) groups are highly sensitive to both light and moisture, and exposure to room temperature or light for several hours can result in a loss of activity of over 50%. Selection of dissolution medium: necessity of non protonated solvents The dissolution of acridine esters requires avoidance of aqueous solutions, which is based on the unique chemical structure. The ester bonds and NHS groups in acridine ester molecules are highly susceptible to nucleophilic attack reactions with water molecules, leading to hydrolysis cleavage. Especially for acridine esters containing NHS groups, their hydrolysis half-life is only a few minutes to a few hours in water, but can be extended to several days or even weeks in non protonated solvents. Therefore, the following two types of solvents should be used to dissolve acridine esters: 1. Polar non proton solvents: such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), which have no active hydrogen in their molecules and cannot provide protons to participate in hydrolysis reactions. At the same time, they can effectively dissolve the hydrophobic acridine ring structure of acridine esters. DMSO has become the most commonly used choice in laboratories due to its low toxicity, high boiling point (189 ℃), and good biocompatibility; DMF is suitable for the preparation of high concentration acridine esters due to its stronger solubility. 2. Mixed solvent system: For extremely insoluble acridine ester derivatives, a mixed solvent of DMSO and acetonitrile (ACN) or dimethylacetamide (DMA) can be used to promote dissolution by adjusting polarity. For example, mixing DMSO and ACN in a volume ratio of 7:3 can reduce the viscosity of the solution while maintaining its non protonated properties, making it easier for subsequent operations. Adaptation of application scenarios: from labeling reaction to luminescence detection The dissolved acridine ester solution can be directly used for chemiluminescence labeling of proteins, antibodies, or nucleic acids. For example, in immunoassays, acridine ester antibody conjugates can bind to antigens in aqueous buffer and subsequently trigger chemiluminescence reactions by adding hydrogen peroxide and sodium hydroxide. It is worth noting that the labeling reaction requires strict control of pH (usually 7.2-7.6) and ionic strength to avoid affecting the luminescence efficiency of acridine esters. Conclusion The dissolution of acridine ester is a key link connecting its stable storage and efficient application. By selecting non protonated solvents, standardizing operating procedures, and adapting to application scenarios, the chemiluminescence potential of acridine esters can be fully released, providing a highly sensitive and specific solution for biological detection. In the future, with the development of new anti hydrolysis acridine ester derivatives, their dissolution and application conditions are expected to be further optimized, promoting breakthroughs in chemiluminescence technology in more fields. As a manufacturer of luminescent reagents, Desheng is currently fully committed to supplying a range of high-quality acridine ester powders. These products are not only convenient to use, but also known for their luminescence sensitivity, ensuring that you can obtain accurate and reliable experimental results in a very short period of time. If you have purchasing needs or would like to learn more details, please feel free to click on our official website for consultation.